The food sector is confronted with a growing number of public and private requirements, which call for provision of information about the quality and sustainability of food, such as, e.g., its origin, safety and production conditions. This forces enterprises to innovate towards demand driven and knowledge-based production of food. As a consequence, intra- and inter-enterprise production and information processes have to be integrated and suitable information systems need to be developed to provide information for related decision processes. The present paper introduces a generalized modelling framework for model-based decision support systems (DSS) involving production and information processes across whole supply networks. The different phases of a decision process are supported by the integration of functional, behavioural and informational network models using the Unified Modeling Language (UML) and discrete-event simulation.