An investigation on argulosis problem and aquaculture condition in Mymensingh area was conducted during the period of August 2004 to June 2005. In the study area, a total of 66 farms were selected for the study. General data were collected through a questionnaire interview from the owners of the farms. Majority of the farms were smaller (5-15 acres) in dize. Among the total fish farmers most of them were educated up to primary level. Mortality of fishes by argulosis was 10% in small farms and 5% in the larger farms. Majority of the farm owners showed their preference for culturing major carps. Mainly June, July and August were the most potential months for Argulus infestation. Labeo rohita and Cirrhinus mrigala were higher susceptible species for Argulosis. Preferable site of infestation on the host body is pectoral region. Brood fishes were more susceptible to Argulus infestation, due to weaker Physiological condition at the breeding season. Principal causes for Argulus infestation was the high stocking density, poor water quality and physical condition of the pond and lack of technical knowledge of the farmers. Most of the farmers used sumithion, dipterex, melathion against argulosis. Proper pond management could control argulosis in fish ponds of this region.