Aqueous and ethanol extracts of twelve indigenous plants were screened for in vitro anthelmintic effect against adult gastrointestinal nematodes of goat origin (Haemonchus contortus, Trichostrongylus spp., Trichuris spp., Strongyloides papillosus, Oesophagostomum columbianum, Cooperia spp. and Buno.stomum trigonocephalum) and their infective larval stage (L3) obtained from in vitro culture. Aqueous extract of the plants showed potent (90-100%) effects against adult g/i nematodes at a concentration of 100 mg/ml whereas in ethanol extracts all plants except Amrul (Oxalis comiculata) were potent only at 50mg/m1 concentration. Ethanol extracts were found to be more effective than aqueous extract against both adult and infective larval stage (L3) comparing at different concentrations. In both cases in vitro activities against adults were much higher than that of infective larvae. Two patent drugs Deminthe (Morantel citrate) and Helmex0 (Albendazole) were included as positive control showed 100% effective against adult worms in vitro.