A pot experiment was conducted at the Bangladesh Institute of Nuclear Agriculture (BINA), Mymensingh, during February to May 2004 to assess the effect of different salinity levels on growth and yield attributes of three sesame cultivars namely BINA TIL-1, T6 and BARI Ti1-3. The salinity levels were control, 6 dS/m and 9 dS/m imposed by irrigation of NaCI salt solution at 45 days after sowing. The experiment was laid out following Randomized Complete Block Design with three replications. Plant height, leaf area, total dry matter, number of capsule per plant, number of seeds per capsule, seed weight per plant, 1000-seed weight and harvest index progressively decreased with the increasing salinity level. BINA Ti1-1 showed better performance on the above morpho-physiological parameters. BARI Ti1-3 had higher Na + in leaves and was found intermediate on the other parameters. T6 showed the lowest yield attributes, K+ content and the highest Na + content in leaves. Salinity tolerance seemed to be better in BINA Ti1-1 followed by BARI Ti!-3 and T6.