The present study was conducted at the laboratories of the Department of Horticulture and the Department of Biochemistry of Bangladesh Agricultural University, Mymensingh during the period of February to July 2003. The effect of different postharvest treatments such as wax coating, CaCl2, Benlate, Dithane M-45, perforated polythene bag and un-perforated polythene bag were studied to evaluate the pattern of chemical changes during storage of two papaya varieties namely, Shahi and Ranchi during storage and ripening. Among the chemical parameters like titratable acidity, vitamin C and ash content declined rapidly in untreated fruits but slowly in treated fruits, while total soluble solids, pulp pH, sugar content (reducing, non-reducing and total) increased steadily in treated fruits but sharply in untreated fruit during storage and ripening.