Indiscriminate and over use of pesticide imposes severe long-term risk to human beings. The exposure level (0.018 mg/kg/day) of pesticides in Bangladesh is much higher than that of expected (0.005 mg/kg/day). Runoff, spillage and leaching of pesticides from agricultural fields contribute pesticide residues in surface and ground water. Ground water and surface water vulnerability in the case of DDT and Atrazine were carried out. Application of 1 to 1.12 kg/ha for Atrazine in low land rice field areas imposes moderate risk on ground water. Adulteration of pesticides in ponds, drainage from irrigation project causes toxicity to fish species and vegetables. Considerable amount of organochlorine insecticides were found in water samples of depressions near rice fields, which indicate lack of control mechanisms. Presence of significant amount of pesticide residue in food, dry fish etc. are matter of concern. The residue of pesticide in human body due to consumption of. rice and wheat was estimated to be 0.62x10-5 mg/day/person. Shetu Pesticide Formulation Ltd., Savar has been observed as a case study and the concept of Pollution Prevention Program (PPP) (EPA, 1982) has been reviewed for the management of industrial waste.