Effects of oral administration of nonsteroidal anti-inflammatory drugs: aspirin and paracetamol in mice

An experiment work was carried out to investigate the effects of oral administration of nonsteroidal antiinflammatory drugs (NSAIDs) on blood glucose level and haematological parameters (TEC, TLC, Hb%, DLC) in mice. Out of three groups of mice (each containing 10 mice), one group was kept as control without giving any drug. Another two groups of mice received separately aspirin (Ecospirin®, 620 mg/kg b.wt.) and paracetamol (Napa®, 333 mg/kg b.wt.) orally along with normal feed. In treated groups, the blood glucose level and total leucocyte count were increased significantly (p<0.01) but the total erythrocyte count (TEC) and haemoglobin content (Hb%) were decreased significantly (p<0.01). In case of differential leukocyte count (DLC), neutrophil count was decreased significantly (p<0.01) but lymphocyte count was increased significantly (p<0.01) in treated groups. In post-mortem examination, congested and hyalinized liver, enlarged kidney and spleen, hemorrhagic stomach and ulcerated intestine were found in NSAIDs treated mice. Long-term oral administration of NSAID is not recommended due to side effects.


Issue Date:
2003-12
Publication Type:
Journal Article
DOI and Other Identifiers:
Record Identifier:
https://ageconsearch.umn.edu/record/276308
ISSN:
2408-8684
Language:
English
Published in:
Journal of the Bangladesh Agricultural University, 01, 1
Page range:
67-70




 Record created 2018-09-19, last modified 2020-10-28

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