Occupational and environmental exposures to pesticides cause a wide range of human health problems. This study assessed the health effect of pesticide use in Egbeda Local Government Area of Oyo State with from socioeconomic point of view by identifying the various pesticides used, describing the health signs and symptoms associated with pesticide application and determining the health effects of pesticide application on farm households. The survey instrument was a well-structured questionnaire administered to respondents through multiple stage sampling technique. A total of 120 respondents were interviewed for the study. Data collected were analysed using descriptive statistics and Tobit regression model. The results showed that commonly used pesticides comprised of herbicides (61.67 %), fungicides (20.0%) and insecticides (18.33%). Majority (95%) reported that they or someone in their family had suffered from pesticide-related health signs and symptoms during or after application of pesticides. The effect of pesticides application on farmer’s health’s was captured by exposure, frequency of exposure and pesticide cocktails. The coefficient of exposure, frequency of exposure and pesticide cocktails were positive and significant at p<0.01, p<0.1and p<0.05 respectively. It is therefore recommended that the awareness of farmers and authorities needs to be raised regarding the use of protective equipment and correct procedures when handling pesticides and, also, that there should be stricter enforcement of existing pesticide regulation and monitoring policies to minimize the threats that farmers’ current practices pose to their health and the livelihood sustainability.