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Abstract
The present study was carried out to investigate the analgesic, anti-inflammatory, antibacterial and antifungal
properties of ethanol leave extract of Mangifera indica. For evaluation of analgesic and anti-inflammatory properties,
acetic acid induced writhing response model and carrageenan induced paw edema model were used in Swiss albino
mice and Wistar albino rats, respectively. In both cases, leaves extract were administered and the obtained effects
were compared with commercially available analgesic and anti-inflammatory drug, Diclofenac Sodium. In analgesic
bioassay, oral administration of the ethanol leaves extract significantly (P<0.01) reduced the writhing response. The
degree of inhibition of leaves extract was 55.8% compared to the effect of standard analgesic drug, Diclofenac
Sodium (75.28%). On the other hand, though leaves extract reduce paw edema but they did not show any significant
effect. The antibacterial and antifungal activity of leaves extract also carried out by disc diffusion technique and
poisoned food technique. In antibacterial experiment, leaves extract showed 7.0 mm to 11.5 mm in diameter of zone
of inhibition against six Gram positive bacteria (such as Staphylococcus aureus, Streptococcus agalactiae, Bacillus
cereus, Bacillus megaterium, Bacillus subtilis and Lactobacillus vulgaricus) and two Gram negative bacteria (such as
Shigella flexneri and Shigella sonei ). But Salmonella typhi and Proteus sp had negative activity on leaves extract.
The leaves extract of Mangifera indica showed antifungal activity against three fungal species (such as Aspergillus
ustus, Aspergillus niger and Aspergillus ochraceus).