An experiment was carried out to evaluate the effects of feeding schedule on growth, production and economics of pangasiid catfish (Pangasius hypophthalmus) and silver carp (Hypophthalmichthys molitrix) polyculture in nine earthen ponds for a period of 135 days. There were three treatments (T) each with three replications. Species composition (1:1) and stocking density (25,000 fish/ha) were same in all treatments. A commercially available pelleted feed was given only for pangasiid catfish with same feeding rate in all treatments but the feeding frequency was different. The feeding rate was 10%, 8%, 7%, 6 %, 5%, 4% which was consecutively adjusted after each fortnightly sampling and 3% for the last 4 weeks of the study period. Feeding frequencies was once a day in T1, two times a day in T2 and three times a day in T3. The average weight gain of pangasiid catfish and silver carp in T3 (376.69 g and 81.02 g) was significantly higher (P<0.05) than those of T2 (330.25 g and 58.35 g) and T1 (261.76 g and 42.89 g). The survival rate was 95.2, 96.0 and 96.8% for pangasiid catfish and 83.2, 85.2 and 86.0% for silver carp in T1, T2 and T3, respectively. The net production of fish in T3 (5,430.64 kg/ha) was significantly higher (P<0.05) than those of T2 (4,584.70 kg/ha) and T1 (3,562.89 kg/ha). Significantly highest net return (Tk. 68,533.54/ha with benefit cost ratio of 1.36) was achieved from T3 followed by T2 (Tk. 40,080.56/ha with benefit cost ratio of 1.22) and T1 (Tk. 13,786.67/ha with benefit cost ratio of 1.08). The present research findings suggest that an increase of feeding frequency has positive effect on growth and production of pangasiid catfish and silver carp.