It is increasingly questionable whether the WTO regime is the most appropriate form of governance for addressing global problems related to agriculture. In particular, climate change, sustainability, hunger/poverty in developing countries, and expected imbalance in food demand-supply by 2050 are emerging as grave challenges to humanity and the WTO is still struggling to resolve issues (related to the multifunctional roles of agriculture) of the 20th century while completely lacking the capacity to tackle such new global issues of the 21st century. Given this outmoded institution, the primary objective of this article is to propose that a new system of governance is needed so as to exclusively and effectively deal with problems arising from the interactions among climate change, agricultural sustainability, food security, and trade.