This paper surveys the literature on pollinator declines and related concerns regarding global food security. Methods for valuing the economic risks associated with pollinator declines are also reviewed. A computable general equilibrium (CGE) approach is introduced to assess the effects of a global catastrophic loss of pollinators. There appears to be evidence supporting a trend towards future pollinator shortages in the United States and other regions of the world. Results from the CGE model show economic risks to both direct crop sectors and indirect non-crop sectors in the economy, with some amount of regional heterogeneity.