Global and climate changes influence the basic conditions for agriculture and so there is not only a demand for a consequent climate protection but also for an adaptation of agriculture to these global changing conditions. For the whole "Maerkisch-Oderland" district (60x40 km) within the moraine landscape of North-East-Germany mainly used for agriculture water balance, nitrogen and sulphur loads as well as crop yields are calculated for two land use and climate scenarios. The comparison between the Scenario2050 and the Scenario2000 reveals significant changes of the water balance (decrease in percolation water, increase in actual evapotranspiration) as well as the concentration of the examined nitrogen in the percolation water. For the study region the crop yields decrease only slightly if the CO2 fertilizing effect is taken into account. Adaptation measures in reaction to the changing climate conditions for an economically secured and sustainable agriculture are recommended.