The life sciences have been the most dynamic area of US university research and commercialization efforts over the past twenty-five years. Using unique data from a large representative sample of life scientists this work examines whether academic patenting and commercialization complement, substitute for, or “hold-up” other research activities. The results highlight the resilience of the basic, federally-funded open scientific research model. Our findings, in turn, underscore the fundamental importance of maintaining the public funding and commitment to the academic, scientific enterprise.