Agriculture as the economic sector is an important factor of economic development of Serbia and an important part of economic structure. Serbia has agrarian resources (land, climate and water) that are not used enough, and therefore, represent a significant economic potential for further development. Vojvodina is the best-developed economic region of the Republic of Serbia, with dominant role of agricultural production. The main economic potential of Vojvodina development is, among other things, the strengthening and improvement of agriculture in the private sector. Economic potential of agriculture impose the need to analyze this situation in the field of small and medium sized entrepreneurship as the bearer of the future development of agriculture in Vojvodina. Cluster analysis is a method that will determine how to group communes in Vojvodina according to the level of development of small and medium-sized enterprises in the field of agriculture, and thus get an insight into the current state of development of this sector of agriculture, as well as point out the possibilities for the future development of SMEs in agribusiness of Vojvodina.