With the development of the biotechnology, more and more GM foods enter the food chain of the mankind. What are the consumers’ attitudes toward those foods? And what are their requirements for safety management derived from the emerging of those foods? By conducting a survey in Wuhan with a sample of 621 correspondents, the study collects the correspondents’ attitudes on GM foods and expectations on safety managements for those foods, and analyses impacts of consumers’ general preferences, specific perceptions on GM foods, and the special labeling usage behavior both on the attitudes formation in GM labeling and on the labeling choices using MNL models. The paper further proposes some suggestions in GM foods safety management based on the modeling results.