Producers’ preferences for cottonseed with respect to price, seed type, yield, and fiber quality are examined by a willingness-to-pay approach via mail surveys. Results indicate a positive willingness to pay (WTP) for technology relative to conventional cottonseed, and WTP increases with the level of technology. Yield and quality also show a positive WTP. Larger farms have a higher WTP for technology, and farms with more farm labor have a lower WTP for technology. These results suggest economies of size in technology adoption (biotechnology is not size-neutral) and that labor and biotechnology are direct substitutes.