The paper examines opportunities for afaltoxin reduction in peanuts. Aflatoxin contamination of peanuts is common in Sub-Saharan Africa including Ghana. Because of its detrimental health effects and economic losses, reduction of aflatoxin contamination in peanuts and peanut products is highly desirable. The paper uses data collected from farmers in the primary peanut growing area, the Northern Region, to illustrate the disparities between the current practices and the desired practices known to reduce aflatoxin presence in peanuts. The outlined containment strategy involves combining the pre- and postharvest methods to aflatoxin reduction proposing the time sequence of implementing individual elements of the strategy.