One hundred and twenty (120) randomly selected youths from Nine (9) states of Nigeria which include Anambra, Ebonyi, Enugu, Kogi, Nasarawa, Niger, Benue, Taraba and Ogun, under the Federal Government of Nigeria (FGN) and International Fund for Agricultural Development (IFAD) sponsored Value Chain Development Programme (VCDP) in collaboration with Building An Economically Sustainable and Integrated Cassava Seed System (BASICS 11 project)were on boarded into the Cassava Seed Entrepreneur programme and trained on good Agronomic Practices (GAP), enterprise development, marketing and business opportunities in the cassava seed system of Nigeria. Baseline information on the socioeconomic characteristics of the trainees, assessment of their cassava varietal preferences as well as the strengths, weaknesses, opportunities and threats to cassava seed entrepreneurship among the youths were obtained through the use of a well-structured questionnaire. Data generated were analyzed using descriptive statistics. Results obtained show that majority of the youths were males (over 60%), belonging to cooperative societies and well educated. Most of them preferred TME 419 variety and among the threats to a successful cassava seed entrepreneurship is the non-involvement of National Agricultural Seed Council. It is therefore recommended that the youths be more engaged in cassava seed business as a means of improving their livelihoods.