The value implication, main contents and practical dimension of integrating the historical initiative spirit into the ideological and political course of colleges and universities were studied. From the perspective of value implication, integrating the historical initiative spirit into the ideological and political course of colleges and universities is helpful to promoting the integrity and innovation of the ideological and political course in colleges and universities, deepening the historical cognition of students and building the cornerstone of students’ belief. From the perspective of main contents, teachers of ideological and political course should clarify the theoretical connotation of the historical initiative spirit, give a thorough exposition of the generation logic of the historical initiative spirit, and explain The Times value of the historical initiative spirit lively. From the perspective of practical dimension, it is necessary to give full play to the educational function of the historical initiative spirit by enriching the content of curriculum teaching, innovating the ways and methods of education and teaching, integrating theory and practice, and online and offline interaction.