During the "14th Five-Year Plan" period, consolidating the achievements of poverty alleviation, promoting rural revitalization and the high-quality development of farmers' cooperatives will overlap at the same time in the spatial field of ethnic minority areas, and they had consistency in content and commonality in value. The high-quality development of farmers' cooperatives in ethnic minority areas is an important organizational way to realize the modernization of agricultural industry, and it is also the key to consolidating the achievements of poverty alleviation and promoting rural revitalization at this stage. Because there is a gap between ethnic minority areas and developed areas in key factors of production such as capital, market, labor and technology, the development of farmers' cooperatives in ethnic minority areas faces more difficulties. This paper takes the development status and outstanding problems of farmers' cooperatives in Guizhou Province as the research object, discusses the connotation and significance of the high-quality development of farmers' cooperatives, and puts forward some strategies and suggestions on the governance of hollowing cooperatives, the allocation of key production factors, and the improvement of the quality of cooperatives.