This paper intends to combine the development trend of the subject, restructure and optimize the course content, and construct the service learning model of Pathogenic Biology of Aquatic Animals for postgraduates. At the same time, through service practice, it is needed to further consolidate curriculum knowledge and skills, stimulate the learning initiative and enthusiasm of postgraduates, expand professional knowledge, improve professional quality, and lay a solid foundation for serving the national rural revitalization strategy in the future.