Preventing, reducing, and improving infection control have been struggles that have preoccupied the World Health Organization for many years. The present study aims to evaluate the efficacy of Bactigel hydro-alcoholic gel on the cutaneous flora of hands. The study was conducted by interviewing people on their knowledge and use of hydro-alcoholic products and culture of palm flora samples before and after hand disinfection. Results showed that 90% of respondents knew about hydro-alcoholic products, 96.3% of whom had already used them, and 92.3% were still used. In addition, 90% do not have alcohol-sensitive skin, and 80% use soap and water with soap for hygiene in their homes. Bactigel significantly reduced the microbial load on palms by 90.04%. Based on these results, Bactigel hydro-alcoholic gel is effective against skin germs. It is concluded that Bactigel can only be effective in the community when compliance is good hand hygiene.