The current state of the Nigerian agricultural system is at a significant level at which an intervention needs to occur. This is more particular due to the role that agriculture plays as a sector in her economy. Whilst the country is endowned with livestock and agricultural friendliness, it is important that its efficiency is sought in order to provide for the best and mass agricultural and livestock produce, both for consumption and business. As a means of achieving this, biotechnology comes into play. Livestock requires a lot of workings in which can mostly be efficient with the use of biotechnology; although it is almost alien in that part of the world. This paper seeks to address biotechnology as a great instrument for the development of livestock in Nigeria.