The purpose of the study is to assess the most important challenges for Ukraine’s agribusiness, as the main sector of the economy, after gaining independence in 1991, with particular emphasis on the full-scale russian invasion. The main directions of overcoming the consequences of russian aggression were systematized. In the process of processing information materials, a dialectical approach to the study of socio-economic phenomena was applied, combined with various methods: induction, analysis and synthesis, systematization and scientific prediction, statistical and computational-constructive. After Ukraine gained independence, agribusiness was the locomotive of its economy. The main damages caused to Ukrainian agribusiness by russian invaders are the direct destruction of agricultural land, its contamination, limiting access to it, disruption of logistics, blocking of ports, destruction of production facilities, crops and animals, theft of agricultural products, increase in production costs. The direct losses of the agricultural sector as a result of the war amounted to over USD 6 billion, and the total losses – to over USD 30 billion. The key directions that should be paid attention to when rebuilding the agro-industrial sector are the storage, logistics and transport infrastructure, as well as the development of science, which will not only allow the reconstruction of Ukrainian agribusiness, but will also enable innovative development of the economy.