Farmers reported that 18.1 million pounds active ingredient (a.i.) of pesticides were applied to soybeans in the Southeast during 1980. This consisted of 11.3 million pounds (a.i.) of herbicides, 5.1 million pounds (a.i.) of insecticides, 1.4 million pounds (a.i.) of nematicides, and 234,000 pounds (a.i.) of fungicides. Pesticide acre-treatments totaled 16.4 million and consisted of 9.7 million with herbicides, 5.8 million with insecticides, 555,000 with nematicides, and 384,000 with fungicides. The primary herbicides were alachlor, bentazon, metribuzin, and trifluralin. The major insecticides were carbaryl and methomyl. Aldicarb and ethylene dibromide were the primary nematicides and benomyl was the major fungicide. Herbicides were applied primarily to control cocklebur and crabgrass infestations, while insecticides were mainly used for armyworm and corn earworm control. Anthracnose and pod and stem blight were the major diseases. Coefficients of variation were computed for acres of soybeans treated with specific pesticide materials.