We provide a comparison between indicators estimated using two of the main global databases used for macroeconomic analysis of GVCs and trade in VA patterns, namely, the GTAP Data Base in its MRIO version and the OECD-WTO TiVA database, and discuss the reasons for the deviation in the estimates of GVC-related trade based on the two databases. This work compares the main global ICIO databases with official macro-economic statistics, and also among themselves to evaluate their accuracy. The latest versions available of both the databases are considered: Version 10 of GTAP and Edition 2018 for TiVA. We analyze the differences between the two databases - harmonized into the same country and sector classification - in structural economic variables, including production, value added, exports and imports, as well as traded intermediate inputs. The major TiVA indicators are estimated based on the two databases and discrepancies among them are discussed.