After poverty has been reduced very successfully around the globe as a consequence of the efforts made under the framework of the Millennium Development Goals, complete eradication of extreme poverty by 2030 has been set as goal number one for the Sustainable Development Goals. However, intuition says that the cost of reaching a goal often increases more than proportionally with decreasing distance to the goal and that the last bit often is excessively costly. This study aims (1) to examine how poverty measurement and poverty targets can be adequately integrated in a holistic, integrated CGE-microsimulation model to study the cost of poverty eradication and (2) to provide a sense of the magnitude of poverty eradication costs by contrasting a number of stylized, more or less targeted policies, using Uganda as a case study.