The purpose of this study is to provide a framework in order to analyze the relation between trade liberalization and food security in Africa. From the 80s, the Bretton Woods institutions consider trade liberalization as a solution to achieve food security in Africa. In this study, the analysis of food security indicators is based on: availability, accessibility and stability / volatility. The situation is that several years after the application of this trade policy, the goal is still not achieved. Thus, reforming agricultural policies in Africa, a fair multilateral trade, the necessary facilities for the African countries to access international markets, and maintaining complementarity between Multilateralism and Regionalism are necessary conditions to promote food security in Africa.