Investment in science and technology is not only a significant indicator to reflect a regional scientific and technological strength and core competitiveness, but also important to technical progress and technology innovation. Investment in science and technology will affect the entire economy through technology innovation. In this paper, we analyze the impact of Beijing’s investment in science and technology on regional economic development and build a Beijing regional CGE model with an econometric module that links the investment in science and technology with technological progress. We found that Investment in science and technology will increase the Beijing GDP , and promote economic structural adjustment. When the real investment in science and technology, increase of 1%, 2%, 3%, Beijing GDP, will respectively increase 0.93, 1.22, 1.51. From the perspective of resident’s income, when investment in science and technology increase by 3%, the level of resident’s income will increase by 3.24 percentage points. In view of the structure perspective of different sector’s investment in science and technology, different investment in sectors will lead to different impact of economic growth and structure, results show that: when the priority of Beijing’s investment of different sector in science and technology is tertiary sectors, agricultural sector, industry sectors, it is conducive to economic growth and industry structure adjustment.