George W. Bush, the US President, announced factual withdrawal from the Kyoto Protocol. In this study, I have used GTAP-E to estimate economic and environmental influences on each country/region by the withdrawal of the US from economic and environmental perspective. In case the US does not ratify the Kyoto Protocol, the US economy will keep stable economic growth. Other Annex countries, Japan and EU, receive both positive and negative impact. Japan and EU have to bear CO2 abatement cost and lose competitiveness against the US, but the abatement cost decrease and increase competitiveness against non-Annex countries. However, the withdrawal of the US carbon-leakage and it worsens not only absolute CHGs emission and also efficiency of carbon dioxide reduction on the whole earth.