[Objectives] To study the activation effect of hydrochemical energy in regenerative agriculture on the nutrients of arsenic sandstone. [Methods] Starting from common environmental factors, moisture, it studied the mechanism of the release and activation of N, P, K nutrient elements in arsenic sandstone under different dry and wet environments. [Results] Water played a positive role in activating soil elements. Under the conditions of long-term dryness and alternating dry and wet conditions, the content of total nitrogen, available phosphorus and available potassium coexisted in the 210 d of culture and the element absorption and release, but the overall trend was increasing; under long-term flooding conditions, the content of total nitrogen and available potassium showed an overall increasing trend during the 210 d of culture, but the content of available phosphorus decreased. [Conclusions] Water plays a positive effect on activating soil elements. The research results are expected to provide a certain reference for the application research of water in regenerative agriculture.