The study reviewed the role of agricultural research in policy making for agricultural development in Nigeria. It specifically identified the salient challenges associated with making agricultural research work for end-users in Nigeria and proffered some solutions using the example of some initiatives implemented by the Agricultural Research Council of Nigeria, ARCN. The major end-users of agricultural research in Nigeria identified include: Research scientists and organizations, training and extension agents/organizations, farmers, industries (producers, consumers and cooperative organizations and policy makers). The major challenges identified include: issues with Funding of research and extension systems, Weak linkage between research, extension and farmers/industries, absence of appropriate communication Strategies and Conflicting expectations from research by various end-user groups. The study noted that the barriers to making agricultural research work for end-users must be addressed via multiple actions at all fronts. The experience of ARCN demonstrated that involvement of end-users in the process of technologies development to solve their challenges enhanced their sense of ownership and makes them more receptive. It has also be confirmed that multi-pronged approach to dissemination of agricultural research results would contribute significantly to making research technologies work for the end-users.