This study estimates wholesale demand for pork, chicken, and quality differentiated beef. We estimate meat retailer own- and cross-price demand elasticities for USDA Choice and Select boxed beef. Results indicate that meat retailers have more elastic demand for lower quality graded beef. Retail beef price has a strong positive relationship with Choice and Select boxed beef demand, and a strong negative relationship with wholesale pork and chicken demand. Seasonal analysis reveals demand for both beef quality grades becomes highly price inelastic during the summer months. The two beef quality grades are substitutes during the winter; however, Select beef is not a substitute for Choice beef in the spring and summer.