In the current process of deepening reform in China, industrial structure upgrading, economic structural transformation and new urbanization are important tasks to promote social and economic development, and technological innovation has gradually become the primary driving force for industrial upgrading, economic transformation and the realization of new urbanization. The article analyzed the action mechanism of scientific and technological innovation on the integration of industrialization and urbanization through qualitative and quantitative methods, found out the prominent problems faced by Henan through the empirical analysis of relevant data of Henan Province, and then proposed the integrated development path driven by scientific and technological innovation.