[Objectives]To screen out the selenium-enriched Pueraria lobata varieties suitable for cultivation in Guangxi according to the natural selenium-enriching ability of 7 main cultivars. [Methods] Taking 7 main cultivars of P. lobata in different places as experimental materials, field cultivation was carried out on the selenium-enriched yellow soil in Shanglin County, Nanning City of Guangxi, to study the difference in selenium-enriching ability of different main cultivars and the comparison of selenium content in different parts, as well as the transport mechanism. [Results] Under the condition of soil selenium content of 0.78 mg/kg, the selenium content of the root tubers of the 7 main cultivars all reached the selenium-enrichment standard. The selenium content of a single root tuber of Heping Variety in Teng County, Guangxi was the highest, at 0.061 mg/kg; Guifenge No.1 was the second at 0.055 mg/kg, and the total selenium accumulation per unit area was the largest. The ranking of selenium content in different parts of the same variety was: leaf > vine > head > root tuber. [Conclusions] Guifenge No.1 has the highest yield and the largest total selenium accumulation, so it is the most suitable natural selenium-enriched variety for cultivation.