This paper describes an innovative graduate course in agricultural economics that has evolved over the past decade and attracts students from across the Purdue University campus. Its novel combination of guest lectures on key sustainability topics, and intensive, computer-based lab assignments with the SIMPLE model of global food and environmental security, prepares students to undertake innovative projects. These independent projects are presented to the class, written up, and submitted in lieu of a final exam. The topics covered are quite diverse and range from the impacts of women empowerment on food security, to the consequences of heat stress on farm workers, and the impact of reducing food waste. The course has spawned two dozen published journal articles, inspired MS and PhD theses, and facilitated a number of important interdisciplinary projects. The complete syllabus, lab assignments, and detailed course design are made available for others to use and adapt to their own circumstances. Future versions of the course will seek to incorporate explicitly spatial analysis of agriculture, land, water, and environmental quality outcomes.