While the influence of regulations on economic outcomes has been well-documented, fewer studies have focused on the economic geography of regulatory burdens. The regulations confronting any supply chain can vary dramatically across legislative jurisdictions, as U.S. policy is enforced by overlapping federal, state, and local governments. In this paper the authors use a unique dataset to explore state-by-state regulatory variation in U.S. beer supply chains in 2020. They find that the state-level laws targeted at the beer supply chain vary between 1,177 and 25,399, with the average state implementing 10,212 formal regulatory restrictions.