Purpose. The aim of the study is to develop a methodical approach to the operational assessment of management system of manufacturing enterprises based on indicators that characterise the organizational structure, management personnel and the effectiveness of its activities. Methodology / method / approach. Theoretical and methodological basis of the study is a dialectical method of cognition, conceptual framework and results of researches conducted by domestic and foreign scientists on the issues of management system of manufacturing enterprises. The research was carried out with modern general and specific scientific methods: abstract-logical – for theoretical generalizations of results of scientific researches and their conclusions; inductive-deductive – to develop a system of indicators for the assessment of enterprise management system; monographic – to deepen the understanding of the concept of «management system»; questionnaire survey of experts – to form the most suitable indicators for operational evaluation. The information base of the study was statistical and financial statement of oil and fat companies. Results. The algorithm of the assessment of management system of manufacturing enterprises is developed. The algorithm is aimed at evaluating the organizational structure of enterprise management, management personnel and the effectiveness of its activities. The optimum sufficient list of indicators to evaluate the management system of manufacturing enterprises is substantiated. The method of the assessment of management system of manufacturing enterprises is offered for practical application. Originality / scientific novelty. For the first time, the article suggests a methodical approach to the assessment of management system of manufacturing enterprises applying appropriate indicators, which does not require additional scientific investigation. Practical value / significance. The proposed methodical approach is supposed to be applied in enterprises for organizing analytical work aimed at the assessment of effectiveness of management system over a span of three, five or more years. The results of the calculations could be useful for annual adjustment (if necessary) of organizational and economic mechanism of enterprise management.