This study examines the influence of adaptive perception on farmers’ adaptive responses to climate change induced natural shocks in the Mekong River Delta (Viet Nam) from a data set of 329 farmers in 2017. Seemingly Unrelated Regression model is used and results show that, controlling for household and household head’s characteristics, farm characteristics, institutional factor, infrastructure, climate conditions, and past climate experiences, adaptive perceptions are the most important factor of adaptive responses. With respect to policy implication, sources and quality of information can be of important consideration due to the potential infl uences on farmers’ adaptive perception and their adaptation assessments. In addition, awareness on climate change and adaptation methods should be highlighted. Other policy options could also be suggested, such as: strengthening education level of farmers, and facilitating cheap technologies for farmers.