[Objectives] This study aimed to compare the effects of water-fertilizer integrated drip irrigation modes and traditional fertilization mode on growth, yield, production costs and economic benefit of sugarcane in latosolic red soil of Guangxi. [Methods] A field test was conducted. [Results] The agronomic traits and comprehensive economic benefit of sugarcane under the water-fertilizer integrated drip irrigation modes were superior to those under the traditional fertilization mode. Among them, the comprehensive economic benefit of sugarcane with special granular fertilizer as the base fertilizer and water-fertilizer integrated drip irrigation as topdressing were the highest, increased by 15 813 kg/ha, an increase of 15.8%. Considering the cost input, the comprehensive economic benefit increased by 5 676 yuan/ha. [Conclusions] Taking the production cost, economic benefit and input-output ratio into account, it is recommended to promote the application of water-fertilizer integrated drip irrigation mode in bases with water and fertilizer equipment conditions.