Using lupin as a break crop and for soil fertility improvement is one of the practices to enhance productivity and improve soil fertility in Ethiopian conditions. However, the use of this practice by smallholder farmers is limited. Therefore, the major objective of this study was to empirically examine factors influencing farmers’ decision to allocate land for lupin crop production as a break crop in North Western Amhara Region of Ethiopia. In this study, stratified sampling procedure was used to select 253 sample households from four Districts (137 household who use lupin in their crop rotations and 116 that do not). The required data were collected using interviews with a structured questionnaire. Logistic regression analysis was used to identify factors influencing farmers’ decision to allocate land for lupin production as a break crop. The results of the logit regression analysis indicate that family size, total farmland holdings and contacts with extension workers were the most important factors influencing the decision of the farmer to practice crop rotation with lupin. Hence, emphasis should be given to improve the human capital through training and providing extension service to bring farmers’ awareness to practice improved technologies and best indigenous knowledge.