With the gradual expansion of the scale and enrollment of colleges and universities in our country, the university education has changed from the elite education to the mass education. The decline of students' quality and the backwardness of the mode of cultivating talents in colleges and universities have resulted in the general low employability of college students and the prominent phenomenon of structural unemployment. Against a background of mass innovation and mass entrepreneurship, colleges and universities should make timely adjustments to the major structure according to social development, cultivate innovative and entrepreneurial talents, and make the objectives and quality of talent training meet the needs of social development. Based on the analysis of the status quo of innovation and entrepreneurship in colleges and universities, especially in agricultural and forestry, normal universities, this paper explores the training model of innovative and entrepreneurial talents in colleges and universities to provide a reference for the training of specialized talents in different disciplines.