Yiwan Economic Corridor is located in the core area of western Jiangxi Province. It is an important part of the middle reaches of the Yangtze River city clusters and the open cooperation pilot zone of Jiangxi and Hunan provinces. The construction of the Yiwan Economic Corridor is an important measure to implement the strategy of “revitalizing and strengthening cities through developing industries”. It is required to deepen the understanding in ideology, grasp the orientation in the thought, and properly deal with relationship in the promotion process. This paper evaluated the advantages and challenges in the construction of Yiwan Economic Corridor, and came up with some recommendations for development of Yiwan Economic Corridor.