Regional economic integration can enhance the overall strength and competitiveness of the zone. The Yangtze River Delta, the Pearl River Delta and the Beijing-Tianjin-Hebei economic circles are the top three zones with economic viability in China. With the development of the economy, these three zones all follow the modern “tertiary, secondary, primary” industrial structure, while the corresponding employment population structure lags behind to a certain extent. Besides, the three major special economic zones are the regions receiving most of the migrant population in China. The inflow of labor has played a double-edged role in local economic and social development. Through systematically comparing the labor market changes in transformation and upgrading of the three major special economic zones, the reform experience could be obtained: urbanization can promote urban employment, industrial agglomeration can attract different employment types, and labor market system reform can enhance labor coordination in the zone.