Cultivating the marine bio-industry cluster is a key industrial strategy for Zhanjiang to seize the manufacturing position of Guangdong's marine economy. By deconstructing the overall scale, characteristics and industrial composition of marine bio-industry cluster and the development status of the industrial parks and bases in Zhanjiang, the resource misallocation coefficient was used to analyze the problems in the marine bio-industry cluster and the resource allocation in Zhanjiang. It is found that in the cultivation of the marine bio-industry cluster in Zhanjiang, the leading effect of leading enterprises needs to be upgraded, the key technologies needs to be broken, the scientific and technological service system needs to be improved, and policy support needs to be strengthened. Moreover, there are serious resource misallocation and high efficiency losses. By optimizing resource allocation, the healthy development of cultivation of marine bio-industry cluster in Zhanjiang will be promoted. To this end, the policy paths that the government can implement are as follows: improving the market access system to appropriately guide medium and small-sized marine enterprises to enter the marine bio-industry, inspiring the marine bio-industry market demand with the industrialization of innovation results as the guide, improving the legal guarantee system to create an innovative atmosphere for the marine bio-industry, and promoting the deepening of the division of labor in the industrial parks.