The ethical conduct of research depends on the informed consent of research participants. Across North America, Institutional Review Boards (IRBs) attempt to guarantee that ethical standards are met and that researchers are familiar with the process of obtaining informed consent. However, incongruities exist across regions, particularly in the developing world. In this paper, we consider informed consent, as practiced by agricultural and applied economists. We examine informed consent material on IRB websites of land grant universities in the United States, as well as at the centers of the CGIAR. We also undertake a survey of researchers at universities to evaluate actual practice of informed consent practices. IRB regulations are clear but heterogeneous, with some universities and CGIAR centers without any ethical review process. Standards often emphasize process, rather than outcome. The lack of IRBs in some contexts and the particulars of the principles employed may fail to protect research participants.