Farmers reported that 124.6 million pounds (a.i.) of pesticides were applied to soybeans in the major producing States during 1980. This consisted of 114.4 million pounds (a.i.) of herbicides, 8 million pounds (a.i.) of insecticides, 1.5 million pounds (a.i.) of nematicides, and 600,000 pounds (a.i.) of fungicides. Pesticide acre-treatments totaled 106.6 million and consisted of 95.5 million with herbicides, 9.3 million with insecticides, 600,000 with nematicides, and 1.2 million with fungicides. The primary herbicides were alachlor, bentazon, and trifluralin. The major insecticides were carbaryl, methomyl, and methyl parathion. Aldicarb and ethylene dibromide were the primary nematicides and benomyl was the major fungicide. Herbicides were applied primarily to control cocklebur, crabgrass, foxtail, and Johnsongrass infestations. Insecticides were mainly applied to control armyworm and corn earworm infestations. Leaf blight, pod and stem blight, and root rot were the major diseases controlled with fungicides. Coefficients of variation were computed for acres of soybeans treated with specific pesticide materials.