College students with economic difficulties are the vulnerable groups who are easy to fall into the predicament of career development. They are mainly characterized as weak career awareness, unclear self-awareness, lack of social resources, and poor comprehensive quality. This paper comprehensively analyzed the predicament of college students and causes. On the basis of causes, it came up with strategies including establishing a perfect whole-process education mechanism, strengthening psychological health and ideological and political education, actively expanding social practice internship platform, and vigorously cultivating employment competitiveness, so as to help students with economic difficulties to get out of their predicament and realize sustainable and comprehensive career development.