In order to make clear the effects of water on yield and agronomic traits of wheat in Cangzhou, 18 wheat cultivars from north part of Huanghuai Plain were collected for spring irrigation. The indoor and field surveys were used to analyze the effects of irrigation frequency on stem tiller situation, leaf area coefficient, yield and other traits of different wheat cultivars. The results indicated that the average yield of irrigation 1 increased by 68.07 kg compared with that of irrigation 0, while the average yield of irrigation 2 increased by 60.00 kg compared with that of irrigation 1. The survey of flag leaf area of wheat cultivars at the grain filling stage showed that the leaf area of irrigation 0 was the smallest (18.15 cm2 on average), the leaf area of irrigation 1 was 20.34 cm2, and the leaf area of irrigation 2 was 24.05 cm2. With the increase in the irrigation times, the volume weight of wheat cultivars declined, the number of infertile spikelet dropped, and the plant height gradually increased. In conclusion, every decrease of one time of irrigation times, there will be loss of yield about 60.00 kg.